1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole → (R)-N-(4-((Chlorodifluoromethyl)thio)phenyl)-6-(3-hydroxypyrrolidin-1-yl)-5-(1H-pyrazol-5-yl)nicotinamide

Participants

Reaction Steps

The title compound was prepared in an analogous fashion to that described in Example 8 using (R)-5-bromo-N-(4-((chlorodifluoromethyl)thio)phenyl)-6-(3-hydroxypyrrolidin-1-yl)nicotinamide (Stage 18.1) and 1-(tetrahydro-2H-pyran-2-yl)-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole to afford an off-white solid. HPLC (Condition 4) tR=4.94 min, UPLC-MS (Condition 3) tR=0.99 min, m/z=466.3 [M+H]+; 1H-NMR (400 MHz, DMSO-d6) δ ppm 1.65-1.88 (m, 2H) 2.86-2.99 (m, 1H) 3.19-3.33 (m, 2H) 3.36-3.51 (m, 1H) 4.13-4.23 (m, 1H) 4.76-4.90 (m, 1H) 6.31-6.42 (m, 1H) 7.65 (d, J=8.21 Hz, 2H) 7.76-7.84 (m, 1H) 7.92 (d, J=8.60 Hz, 2H) 7.98-8.08 (m, 1H) 8.66-8.82 (m, 1H) 10.28 (s, 1H) 12.82-13.14 (m, 1H).

Provenance & Evidence