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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 737823Generated: October 30, 2026

p-Toluidine → 4-ethyl-N-(4-methylphenyl)aniline

https://huagongshe.com/reaction/737823

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-ToluidineHCID 7813—
Reactant1-Ethyl-4-iodobenzeneHCID 141189—
ReagentIsoxazole, 5-phenyl-HCID 136800—
Reagent2-tert-Butyl-1,1,3,3-tetramethylguanidineHCID 3571581—
CatalystHCID 178492609HCID 178492609—
SolventDimethyl SulfoxideHCID 679—
Product4-ethyl-N-(4-methylphenyl)anilineHCID 2081671273.74%

Reaction Conditions

Temperature60 °C

Reaction Steps

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Provenance & Evidence

DOI10.1126/science.aar5169
Source datasetAhneman
ORD IDord-2bce8301a53e4610acb001866224e454
Source noteAhneman