HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-fluoro-5-(tributylstannyl)-1H-pyrazole → 6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)-5-(4-fluoro-1H-pyrazol-5-yl)nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-fluoro-5-(tributylstannyl)-1H-pyrazole | HCID 11153044 | — |
| Reactant | 6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)-5-iodonicotinamide | HCID 86702626 | — |
| Product | 6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)-5-(4-fluoro-1H-pyrazol-5-yl)nicotinamide | HCID 86702625 | — |
Reaction Steps
The title compound was prepared in an analogous fashion to that described in Stage 13.1 using 6-chloro-N-(4-(chlorodifluoromethoxy)phenyl)-5-iodonicotinamide (Stage 25.2) and 4-fluoro-5-(tributylstannyl)-1H-pyrazole to afford an off-white powder. HPLC (Condition 4) tR=5.69 min, UPLC-MS (Condition 3) tR=1.09 min, m/z=415 [M−H]−; 1H-NMR (400 MHz, DMSO-d6) δ ppm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08829195B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-daadfea8970f45eabd880d8089854eb8 |
| Source note | uspto-grants-2014_09 |