Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 737906Generated: October 30, 2026

p-Toluidine → 4-methyl-N-(4-(trifluoromethyl)phenyl)aniline

https://huagongshe.com/reaction/737906

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-ToluidineHCID 7813—
ReactantBenzene, 1-bromo-4-(trifluoromethyl)-HCID 67872—
ReagentEthyl 5-methylisoxazole-3-carboxylateHCID 76677—
Reagent2-tert-Butyl-1,1,3,3-tetramethylguanidineHCID 3571581—
CatalystHCID 178492609HCID 178492609—
SolventDimethyl SulfoxideHCID 679—
Product4-methyl-N-(4-(trifluoromethyl)phenyl)anilineHCID 1871279941.678%

Reaction Conditions

Temperature60 °C

Reaction Steps

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Provenance & Evidence

DOI10.1126/science.aar5169
Source datasetAhneman
ORD IDord-9babce54a97e4867a2126339c2f566b0
Source noteAhneman