5-Bromo-6-chloropyridine-3-carboxylic acid → HCID 86702634, compound

HRID 73805Notes

Reaction equation

HRID 73805 reaction equation
[Br:1][C:2]1[C:3]([Cl:11])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([OH:9])=O.[F:12][C:13]([F:23])([F:22])[S:14][C:15]1[N:20]=[CH:19][C:18]([NH2:21])=[CH:17][CH:16]=1>>[Br:1][C:2]1[C:3]([Cl:11])=[N:4][CH:5]=[C:6]([CH:10]=1)[C:7]([NH:21][C:18]1[CH:19]=[N:20][C:15]([S:14][C:13]([F:23])([F:22])[F:12])=[CH:16][CH:17]=1)=[O:9]

Participants

3

Reactant 2

HCID 2854335-Bromo-6-chloropyridine-3-carboxylic acidHCID 436250226-(Ttrifluoromethylthio)pyridin-3-amine

Product 1

HCID 86702634HCID 86702634, compound

Procedure

The title compound was prepared in an analogous fashion to that described in Stage 9.3 using 5-bromo-6-chloronicotinic acid and 6-(trifluoromethylthio)pyridin-3-amine to afford an off-white powder. HPLC (Condition 4) tR=6.43 min, UPLC-MS (Condition 3) tR=1.15 min, m/z=411.9 [M−H]−.

Workup

  1. customto afford an off-white powder

Sources & evidence

ORD record
ord-6ee8571305a044d68682dfacec6ed401
Source dataset
uspto-grants-2014_09
Patent number
US08829195B2

Reaction notes

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