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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 738060Generated: October 29, 2026

p-Toluidine → 4-Methoxy-4'-methyldiphenylamine

https://huagongshe.com/reaction/738060

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-ToluidineHCID 7813—
Reactant4-IodoanisoleHCID 69676—
ReagentIsoxazole, 3-methyl- (8CI)(9CI)HCID 96098—
Reagent7-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-eneHCID 123583—
CatalystHCID 178439018HCID 178439018—
SolventDimethyl SulfoxideHCID 679—
Product4-Methoxy-4'-methyldiphenylamineHCID 1143582827.38%

Reaction Conditions

Temperature60 °C

Reaction Steps

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Provenance & Evidence

DOI10.1126/science.aar5169
Source datasetAhneman
ORD IDord-52ea38f7c4954b458fe56654204766a0
Source noteAhneman