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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 738475Generated: October 30, 2026

p-Toluidine → 4-ethyl-N-(4-methylphenyl)aniline

https://huagongshe.com/reaction/738475

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-ToluidineHCID 7813—
Reactant1-Bromo-4-ethylbenzeneHCID 15313—
Reagent4-PhenylisoxazoleHCID 2750134—
Reagent2,N'3,N'3,N3,N3,N'5,N'5,N5,N5-nonamethyl-2,4,6-triaza-3lambda5,5lambda5-diphosphaocta-3,5-diene-3,3,5,5-tetramineHCID 3393106—
CatalystHCID 178492609HCID 178492609—
SolventDimethyl SulfoxideHCID 679—
Product4-ethyl-N-(4-methylphenyl)anilineHCID 2081671223.316%

Reaction Conditions

Temperature60 °C

Reaction Steps

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Provenance & Evidence

DOI10.1126/science.aar5169
Source datasetAhneman
ORD IDord-a9f1ac9c30c14d0c99e83aa3fb352163
Source noteAhneman