反应详情

A solution of 491 mg (2 mmol) of 2-[(E)-2-(2-furanyl)ethenyl]-3-oxo-1-azaspiro[4.5]dec-1-en-4-one and 597 mg (4 mmol) of L-methionine in 20 ml of N-methylmorpholine was heated under reflux for 15 hours. After ethyl acetate and water were added to the reaction solution, the mixture was acidified using concentrated hydrochloric acid. The organic layer was separated and successively washed with water and saturated brine, followed by drying with anhydrous sodium sulfate. After the solvent was distilled off under reduced pressure, the residue was purified by silica gel chromatography to obtain 74 mg (9%) of the title compound.

1. temperatureunder reflux for 15 hours
2. customThe organic layer was separated
3. washsuccessively washed with water and saturated brine
4. dry with materialby drying with anhydrous sodium sulfate
5. distillationAfter the solvent was distilled off under reduced pressure
6. customthe residue was purified by silica gel chromatography