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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 738809Generated: October 30, 2026

p-Toluidine → 3-Pyridinamine, N-(4-methylphenyl)-

https://huagongshe.com/reaction/738809

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-ToluidineHCID 7813—
Reactant3-ChloropyridineHCID 12287—
ReagentMethyl isoxazole-5-carboxylateHCID 2736892—
Reagent2-tert-Butyl-1,1,3,3-tetramethylguanidineHCID 3571581—
CatalystHCID 178439018HCID 178439018—
SolventDimethyl SulfoxideHCID 679—
Product3-Pyridinamine, N-(4-methylphenyl)-HCID 6035890.895%

Reaction Conditions

Temperature60 °C

Reaction Steps

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Provenance & Evidence

DOI10.1126/science.aar5169
Source datasetAhneman
ORD IDord-e2f7596c65f3472e9bac5c938a2ddb08
Source noteAhneman