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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 738816Generated: October 30, 2026

4-Bromoanisole → 4-Methoxy-4'-methyldiphenylamine

https://huagongshe.com/reaction/738816

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-BromoanisoleHCID 7730—
Reactantp-ToluidineHCID 7813—
Reagent7-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-eneHCID 123583—
ReagentMethyl isoxazole-5-carboxylateHCID 2736892—
CatalystHCID 178439018HCID 178439018—
SolventDimethyl SulfoxideHCID 679—
Product4-Methoxy-4'-methyldiphenylamineHCID 114358282.786%

Reaction Conditions

Temperature60 °C

Reaction Steps

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Provenance & Evidence

DOI10.1126/science.aar5169
Source datasetAhneman
ORD IDord-f57972b58e07465f8d311a9c57cfa674
Source noteAhneman