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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 738962Generated: October 30, 2026

1-Chloro-4-(trifluoromethyl)benzene → 4-methyl-N-(4-(trifluoromethyl)phenyl)aniline

https://huagongshe.com/reaction/738962

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Chloro-4-(trifluoromethyl)benzeneHCID 7394—
Reactantp-ToluidineHCID 7813—
ReagentMethyl isoxazole-5-carboxylateHCID 2736892—
Reagent2,N'3,N'3,N3,N3,N'5,N'5,N5,N5-nonamethyl-2,4,6-triaza-3lambda5,5lambda5-diphosphaocta-3,5-diene-3,3,5,5-tetramineHCID 3393106—
CatalystHCID 178439023HCID 178439023—
SolventDimethyl SulfoxideHCID 679—
Product4-methyl-N-(4-(trifluoromethyl)phenyl)anilineHCID 187127998.912%

Reaction Conditions

Temperature60 °C

Reaction Steps

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Provenance & Evidence

DOI10.1126/science.aar5169
Source datasetAhneman
ORD IDord-b0c336752d934c228f1e484bec47e226
Source noteAhneman