Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 738985Generated: October 29, 2026

p-Toluidine → 4-ethyl-N-(4-methylphenyl)aniline

https://huagongshe.com/reaction/738985

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-ToluidineHCID 7813—
Reactant1-Ethyl-4-iodobenzeneHCID 141189—
ReagentMethyl isoxazole-5-carboxylateHCID 2736892—
Reagent2-tert-Butyl-1,1,3,3-tetramethylguanidineHCID 3571581—
CatalystHCID 178439023HCID 178439023—
SolventDimethyl SulfoxideHCID 679—
Product4-ethyl-N-(4-methylphenyl)anilineHCID 2081671250.622%

Reaction Conditions

Temperature60 °C

Reaction Steps

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Provenance & Evidence

DOI10.1126/science.aar5169
Source datasetAhneman
ORD IDord-419bea6c6f6547c7bd6685599d655334
Source noteAhneman