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Diphenyl Ether → Ethyl 4,5-dioxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diphenyl Ether | HCID 7583 | — |
| 反応物 | diethyl N-(3-oxo-1-cyclohexen-1-yl)-aminomethylenemalonate | HCID 12877078 | — |
| 溶媒 | Hexane | HCID 8058 | — |
| 生成物 | Ethyl 4,5-dioxo-1,4,5,6,7,8-hexahydroquinoline-3-carboxylate | HCID 12876362 | 722.7% |
反応手順
A mixture of 2-[(3-oxo-cyclohex-1-enylamino)-methylene]-malonic acid diethyl ester (2.8 g, 1 mmol) and diphenylether (20 mL) was refluxed for 15 min. After cooling, n-hexane (80 mL) was added. The resulting solid was isolated via filtration and recrystallized from methanol to give 4,5-dioxo-1,4,5,6,7,8-hexahydro-quinoline-3-carboxylic acid ethyl ester (1.7 g 72%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08829204B2 |
| 出典データセット | uspto-grants-2014_09 |
| ORD ID | ord-d7e2103dc6ce46ac8fe5e62d071c8f7e |
| 出典メモ | uspto-grants-2014_09 |