Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 739067Generated: November 1, 2026

1-Chloro-4-(trifluoromethyl)benzene → 4-methyl-N-(4-(trifluoromethyl)phenyl)aniline

https://huagongshe.com/reaction/739067

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Chloro-4-(trifluoromethyl)benzeneHCID 7394—
Reactantp-ToluidineHCID 7813—
Reagent2,1-BenzisoxazoleHCID 67498—
Reagent2-tert-Butyl-1,1,3,3-tetramethylguanidineHCID 3571581—
CatalystHCID 178492620HCID 178492620—
SolventDimethyl SulfoxideHCID 679—
Product4-methyl-N-(4-(trifluoromethyl)phenyl)anilineHCID 187127990%

Reaction Conditions

Temperature60 °C

Reaction Steps

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Provenance & Evidence

DOI10.1126/science.aar5169
Source datasetAhneman
ORD IDord-d36b1cd16d26430cbccfc4e3d7ee5bd4
Source noteAhneman