Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 739227Generated: November 1, 2026

p-Toluidine → 2-Pyridinamine, N-(4-methylphenyl)-

https://huagongshe.com/reaction/739227

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-ToluidineHCID 7813—
Reactant2-BromopyridineHCID 7973—
Reagent5-MethylisoxazoleHCID 79833—
Reagent7-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-eneHCID 123583—
CatalystHCID 178492609HCID 178492609—
SolventDimethyl SulfoxideHCID 679—
Product2-Pyridinamine, N-(4-methylphenyl)-HCID 278641982.571%

Reaction Conditions

Temperature60 °C

Reaction Steps

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Provenance & Evidence

DOI10.1126/science.aar5169
Source datasetAhneman
ORD IDord-5300899d309a4d389d29fdb4cb59c722
Source noteAhneman