反应详情

温度

5 °C

To a solution of 5-bromo-2,3-dihydro-1H-indole (45 g, 0.227 mol) in H2SO4 (98%, 200 mL) was slowly added KNO3 (23.5 g, 0.23 mol) at 0° C. After addition, the mixture was stirred at 0-10° C. for 4 h, carefully poured into ice, basified with Na2CO3 to pH 8 and extracted with ethyl acetate. The combined organic extracts were washed with brine, dried over Na2SO4 and concentrated to dryness. The residue was purified by column chromatography on silica gel to give 5-bromo-6-nitro-2,3-dihydro-1H-indole (42 g, 76%).

1. customat 0° C
2. additionAfter addition
3. additioncarefully poured into ice
4. extractionextracted with ethyl acetate
5. washThe combined organic extracts were washed with brine
6. dry with materialdried over Na2SO4
7. concentrationconcentrated to dryness
8. customThe residue was purified by column chromatography on silica gel