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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 739655Generated: October 28, 2026

p-Toluidine → 4-Methoxy-4'-methyldiphenylamine

https://huagongshe.com/reaction/739655

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-ToluidineHCID 7813—
Reactant4-ChloroanisoleHCID 12167—
Reagent2-tert-Butyl-1,1,3,3-tetramethylguanidineHCID 3571581—
ReagentEthyl 1,2-oxazole-4-carboxylateHCID 15590757—
CatalystHCID 178439023HCID 178439023—
SolventDimethyl SulfoxideHCID 679—
Product4-Methoxy-4'-methyldiphenylamineHCID 114358280%

Reaction Conditions

Temperature60 °C

Reaction Steps

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Provenance & Evidence

DOI10.1126/science.aar5169
Source datasetAhneman
ORD IDord-a906af2177bf4badb84739888349386d
Source noteAhneman