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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 739744Generated: October 29, 2026

p-Toluidine → 4-methyl-N-(4-(trifluoromethyl)phenyl)aniline

https://huagongshe.com/reaction/739744

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-ToluidineHCID 7813—
ReactantBenzene, 1-iodo-4-(trifluoromethyl)-HCID 67993—
Reagent2-tert-Butyl-1,1,3,3-tetramethylguanidineHCID 3571581—
Reagentethyl isoxazole-3-carboxylateHCID 10034712—
CatalystHCID 178492620HCID 178492620—
SolventDimethyl SulfoxideHCID 679—
Product4-methyl-N-(4-(trifluoromethyl)phenyl)anilineHCID 1871279935.615%

Reaction Conditions

Temperature60 °C

Reaction Steps

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Provenance & Evidence

DOI10.1126/science.aar5169
Source datasetAhneman
ORD IDord-84731fde61c34d94b4e857c300d679a9
Source noteAhneman