Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 739748Generated: October 29, 2026

p-Toluidine → 4-ethyl-N-(4-methylphenyl)aniline

https://huagongshe.com/reaction/739748

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-ToluidineHCID 7813—
Reactant1-Chloro-4-ethylbenzeneHCID 69330—
Reagent2-tert-Butyl-1,1,3,3-tetramethylguanidineHCID 3571581—
Reagentethyl isoxazole-3-carboxylateHCID 10034712—
CatalystHCID 178492620HCID 178492620—
SolventDimethyl SulfoxideHCID 679—
Product4-ethyl-N-(4-methylphenyl)anilineHCID 208167126.866%

Reaction Conditions

Temperature60 °C

Reaction Steps

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Provenance & Evidence

DOI10.1126/science.aar5169
Source datasetAhneman
ORD IDord-60bf9c10eb4d4ff989a6fc8f1c3df6bc
Source noteAhneman