Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 739756Generated: October 31, 2026

p-Toluidine → 3-Pyridinamine, N-(4-methylphenyl)-

https://huagongshe.com/reaction/739756

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-ToluidineHCID 7813—
Reactant3-IodopyridineHCID 70714—
Reagent2-tert-Butyl-1,1,3,3-tetramethylguanidineHCID 3571581—
Reagentethyl isoxazole-3-carboxylateHCID 10034712—
CatalystHCID 178492620HCID 178492620—
SolventDimethyl SulfoxideHCID 679—
Product3-Pyridinamine, N-(4-methylphenyl)-HCID 60358964.64%

Reaction Conditions

Temperature60 °C

Reaction Steps

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Provenance & Evidence

DOI10.1126/science.aar5169
Source datasetAhneman
ORD IDord-938a9ded3a8741abb7a79492d0e4bc22
Source noteAhneman