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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 739766Generated: October 30, 2026

p-Toluidine → 2-Pyridinamine, N-(4-methylphenyl)-

https://huagongshe.com/reaction/739766

Reaction equation

Participants

RoleNameHCIDCharge
Reactantp-ToluidineHCID 7813—
Reactant2-ChloropyridineHCID 7977—
Reagent7-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-eneHCID 123583—
Reagentethyl isoxazole-3-carboxylateHCID 10034712—
CatalystHCID 178492620HCID 178492620—
SolventDimethyl SulfoxideHCID 679—
Product2-Pyridinamine, N-(4-methylphenyl)-HCID 278641984.93%

Reaction Conditions

Temperature60 °C

Reaction Steps

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Provenance & Evidence

DOI10.1126/science.aar5169
Source datasetAhneman
ORD IDord-c3f64aeb21b04b8398be05960d94a73f
Source noteAhneman