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0 °C

In a 150 ml three necked flask fitted with magnetic stirrer and reflux condenser, under inert atmosphere, 6.88 g (23.5 nmoles) of {1-[(1S)-1-(aminocarbonyl)propyl]-6-oxo-3-piperidinyl}methyl methanesulfonate 24 were dissolved in 86 ml of THF. 3.9 g (25.9 mmoles, 1.1 eq) of sodium iodide were added in one portion and the mixture was brought to reflux. After 5 hours, 780 mg (5.2 mmoles, 0.22 eq) of sodium iodide were added and reflux continued for a total of 10 hours. After cooling down to 0° C., the mixture was filtered, the precipitate washed with THF, the combined organic fractions concentrated to dryness and purified by PrepLC (800 g SiO2, CH2Cl2/MeOH, 95/5) to give 7.21 g of crude compound. It was crystallised from 80 ml ethanol to give 5 g of pure iodide 13, 66% yield.

1. temperaturereflux condenser
2. temperatureto reflux
3. temperaturereflux
4. customcontinued for a total of 10 hours
5. filtrationthe mixture was filtered
6. washthe precipitate washed with THF
7. concentrationthe combined organic fractions concentrated to dryness
8. custompurified by PrepLC (800 g SiO2, CH2Cl2/MeOH, 95/5)
9. customto give 7.21 g of crude compound
10. customIt was crystallised from 80 ml ethanol