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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 739967Generated: October 30, 2026

1-Chloro-4-(trifluoromethyl)benzene → 4-methyl-N-(4-(trifluoromethyl)phenyl)aniline

https://huagongshe.com/reaction/739967

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Chloro-4-(trifluoromethyl)benzeneHCID 7394—
Reactantp-ToluidineHCID 7813—
Reagent2-tert-Butyl-1,1,3,3-tetramethylguanidineHCID 3571581—
ReagentEthyl 5-methylisoxazole-4-carboxylateHCID 7009317—
CatalystHCID 178492609HCID 178492609—
SolventDimethyl SulfoxideHCID 679—
Product4-methyl-N-(4-(trifluoromethyl)phenyl)anilineHCID 187127990%

Reaction Conditions

Temperature60 °C

Reaction Steps

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Provenance & Evidence

DOI10.1126/science.aar5169
Source datasetAhneman
ORD IDord-26be189d3f1b49a6b9c247c6bcd2cbfb
Source noteAhneman