HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 2-Tert-butyl-4-bromo-5-nitrophenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Hydroxide | HCID 14797 | — |
| Reactant | 4-Bromo-2-(tert-butyl)-5-nitrophenyl methyl carbonate | HCID 57470235 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 2-Tert-butyl-4-bromo-5-nitrophenol | HCID 57470236 | 99.7% |
Reaction Steps
To a solution of methyl (2-tert-butyl-4-bromo-5-nitrophenyl) carbonate (121.5 g, 0.366 mol) in methanol (1000 mL) was added potassium hydroxide (30.75 g, 0.549 mol) in portions. After addition, the mixture was stirred at room temperature for 3 h and acidified with 1N HCl to pH 7. Methanol was removed and water was added. The mixture was extracted with ethyl acetate and the organic layer was separated, dried over Na2SO4 and concentrated to give 2-tert-butyl-4-bromo-5-nitro-phenol (C-14-a) (100 g, 99%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08829204B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-8edaf5542c3e41b18d7b29761a3a1873 |
| Source note | uspto-grants-2014_09 |