反应详情

温度

50 °C

In a 150 ml three necked flask fitted with reflux condenser, magnetic stirrer and dropping funnel under inert atmosphere, 5.09 g (27.5 mmoles, 1 eq) of ethyl 7-oxo-4-azepanecarboxylate 28 and 12.27 g (55 mmoles, 2 eq) of tert-butyl 2-bromobutanoate were dissolved in 70 ml of acetonitrile. The temperature was raised to 50° C. and 1.32 g (55 mmoles, 2 eq) of sodium hydride were added portionwise (exothermic). The mixture was stirred one more hour at 50° C. and concentrated to dryness, the residue was poured on ice/water and neutralised with solid ammonium chloride. The mixture was extracted three times with CH2Cl2, the combined organic phases were dried over magnesium sulfate, filtered and concentrated to dryness. The residue was purified by PrepLC (1 kg SiO2, CH2Cl2/MTBE, 85/15) to give 8.5 g of pure diester 29, 69% yield.

1. temperaturewith reflux condenser, magnetic stirrer
2. concentrationconcentrated to dryness
3. additionthe residue was poured on ice/water and neutralised with solid ammonium chloride
4. extractionThe mixture was extracted three times with CH2Cl2
5. dry with materialthe combined organic phases were dried over magnesium sulfate
6. filtrationfiltered
7. concentrationconcentrated to dryness
8. customThe residue was purified by PrepLC (1 kg SiO2, CH2Cl2/MTBE, 85/15)