HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-[2-(2-Methoxy-ethoxy)-1,1-dimethyl-ethyl]-4-nitro-benzene → 4-[2-(2-Methoxy-ethoxy)-1,1-dimethyl-ethyl]-phenylamine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-[2-(2-Methoxy-ethoxy)-1,1-dimethyl-ethyl]-4-nitro-benzene | HCID 57482697 | — |
| Catalyst | Nickel | HCID 935 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-[2-(2-Methoxy-ethoxy)-1,1-dimethyl-ethyl]-phenylamine | HCID 57482698 | 77% |
Reaction Steps
A suspension of 1-[2-(2-methoxy-ethoxy)-1,1-dimethyl-ethyl]-4-nitro-benzene (8.1 g, 32 mmol) and Raney Ni (1 g) in MeOH (50 mL) was stirred under H2 (1 atm) at room temperature for 1 h. The catalyst was filtered off and the filtrate was concentrated to obtain 4-[2-(2-methoxy-ethoxy)-1,1-dimethyl-ethyl]-phenylamine (5.5 g, 77%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08829204B2 |
| Source dataset | uspto-grants-2014_09 |
| ORD ID | ord-c12ab6549745410ca04dddb071c4c12e |
| Source note | uspto-grants-2014_09 |