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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 740297Generated: November 3, 2026

1-Chloro-4-(trifluoromethyl)benzene → 4-methyl-N-(4-(trifluoromethyl)phenyl)aniline

https://huagongshe.com/reaction/740297

Reaction equation

Participants

RoleNameHCIDCharge
Reactant1-Chloro-4-(trifluoromethyl)benzeneHCID 7394—
Reactantp-ToluidineHCID 7813—
Reagent7-Methyl-1,5,7-triazabicyclo[4.4.0]dec-5-eneHCID 123583—
Reagent3-Methoxy-5-carbethoxy-isoxazoleHCID 19958817—
CatalystHCID 178439023HCID 178439023—
SolventDimethyl SulfoxideHCID 679—
Product4-methyl-N-(4-(trifluoromethyl)phenyl)anilineHCID 1871279924.482%

Reaction Conditions

Temperature60 °C

Reaction Steps

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Provenance & Evidence

DOI10.1126/science.aar5169
Source datasetAhneman
ORD IDord-eb76dc4953e1466289f88342a3482ba9
Source noteAhneman