Back
HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 741051Generated: October 31, 2026

4-Bromoanisole → 4-Methoxy-4'-methyldiphenylamine

https://huagongshe.com/reaction/741051

Reaction equation

Participants

RoleNameHCIDCharge
Reactant4-BromoanisoleHCID 7730—
Reactantp-ToluidineHCID 7813—
Reagent2-tert-Butyl-1,1,3,3-tetramethylguanidineHCID 3571581—
ReagentHCID 178420340HCID 178420340—
CatalystHCID 178439023HCID 178439023—
SolventDimethyl SulfoxideHCID 679—
Product4-Methoxy-4'-methyldiphenylamineHCID 114358285.936%

Reaction Conditions

Temperature60 °C

Reaction Steps

These solutions were added to a 384- well source plate (80 µL per well). The Mosquito HTS liquid handling robot was used to dose each of these solutions (200 nL each) into a 1536-well plate.

Provenance & Evidence

DOI10.1126/science.aar5169
Source datasetAhneman
ORD IDord-33f93cb1c8004c9caf78574f86568ed3
Source noteAhneman