Methyl Ethyl Ketone → HCID 86749780, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of N-methyl-2-propen-1-amine (2.7 ml), ethyl 3-bromo-propanoate (4.5 ml) and potassium carbonate (5.8 g) in 2-butanone (20 ml) was stirred at 50° C. for 4 hours. The mixture was cooled to room temperature, filtered and the filtrate evaporated. The residue was dissolved in water, extracted with CH2Cl2 and the solvent evaporated. The residue was purified by column chromatography over silica gel (eluent: CH2Cl2 /CH3OH 9.75/0.25). The pure fractions were collected and evaporated, yielding 3 g (63%) of ethyl N-methyl-N-2-propenyl-β-alanine (interm. 3).

Provenance & Evidence