HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methylindole-3-carboxylic acid → Quinolizidin-2-ylmethyl-1-methylindole-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methylindole-3-carboxylic acid | HCID 854040 | — |
| Reactant | Octahydro-2H-quinolizine-2-methanol | HCID 70077295 | — |
| Product | Quinolizidin-2-ylmethyl-1-methylindole-3-carboxylate | HCID 131719523 | — |
Reaction Steps
eq-2-Hydroxymethylquinolizidine (N. J. Leonard et al, J. Org. Chem., 1957, 22, 1445) was reacted with the acid chloride of 1-methylindole-3-carboxylic acid using the method of Example 1. The product was chromatographed on silica gel eluting with ethyl acetate. The resulting pale yellow oil was crystallised from n-pentane to afford the title compound (E15) as a white crystalline solid mp 115°-116° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05552398 |
| Source dataset | uspto-grants-1996_09 |
| ORD ID | ord-50a1fb1b1f1d47c88ee9b76c062fb496 |
| Source note | uspto-grants-1996_09 |