1-ethyl-1H-indole-3-carboxylic acid → Quinolizidin-2-ylmethyl-1-ethylindole-3-carboxylate

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Reaction Steps

eq-2-Hydroxymethylquinolizidine (N. J. Leonard et al, J. Org. Chem., 1957, 22, 1445) was reacted with the acid chloride of 1-ethylindole-3-carboxylic acid using the method of Example 1. The product was chromatographed on silica gel eluting with ethyl acetate to afford the title compound (E16) as a pale yellow oil. This was converted to its hydrochloride salt mp 168°-172° C.

Provenance & Evidence