Allyl iodide → Quinolizidin-2-ylmethyl-1-allylindole-3-carboxylate

Participants

Reaction Steps

eq-Quinolizidin-2-ylmethylindole-3-carboxylate (E9b) was alkylated with allyl iodide using the method in Example 18. The product was chromatographed on silica gel eluting initially with ether, then with ethyl acetate, to afford the title compound (E19) as a colourless oil. This was converted to its hydrochloride salt mp 190°-192° C. (acetone)

Provenance & Evidence