HuagongsheHuagongshe Chemistry Print Report · For research reference only
Bromomethylcyclopropane → HCID 67836608, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Bromomethylcyclopropane | HCID 81503 | — |
| Reactant | Quinolizidin-2-ylmethylindole-3-carboxylate | HCID 131719520 | — |
| Product | HCID 67836608 | HCID 67836608 | — |
Reaction Steps
eq-Quinolizidin-2-ylmethyl indole-3-carboxylate (E9b) was alkylated with cyclopropylmethyl bromide using the method in Example 18. The product was chromatographed on silica gel eluting initially with ether, then with ethyl acetate, to afford the title compound (E28) as a colourless oil. This was converted to its hydrochloride salt mp 167°-169° C. (acetone/ether).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05552398 |
| Source dataset | uspto-grants-1996_09 |
| ORD ID | ord-48d8eae9c88944c388832a59759f9cbd |
| Source note | uspto-grants-1996_09 |