Sodium Carbonate → HCID 67836505, compound

Participants

Reaction Steps

A stirred solution of eq-quinolizidin-2-ylmethylindole-3-carboxylate (E9b) (300 mg, 0.96 mmol) in acetone (10 ml) was treated with anhydrous potassium carbonate (270 mg, 2 mmole) and bromoacetone (150 mg, 1.1 mmole) and kept at room temperature for 3 days. The mixture was treated with 10% Na2CO3 solution (10 ml) and extracted with ethyl acetate (2×25 ml). The combined extracts were dried (Na2SO4), concentrated in vacuo and the residue chromatographed on silica gel eluting with ethyl acetate/methanol (95:5). The pale yellow oil obtained was crystallised from ether to afford the title compound (E31) as a beige solid (14 mg) mp 139°-1420C.

Provenance & Evidence