Hydrazine hydrate (1:1) → 6-(4-Chlorophenyl)-4,5-Dihydropyridazin-3(2H)-One

Participants

Reaction Steps

To a solution of 3-(4-chlorobenzoyl)propionic acid (20 g) in absolute ethanol (200 ml) was added 5 g of hydrazine monohydrate. A thick solid was formed which dissolved after heating. The resulting solution was refluxed for 3 h, cooled and the solid formed filtered and dried to yield 16 g (80%) of 6-(4-chlorophenyl)-4,5-dihydropyridazinone.

Provenance & Evidence