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HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 741599Erstellt: 25. Oktober 2026

5-(4-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrile → 5-(4-Chlorophenyl)-2-hydroxypyridine

https://huagongshe.com/reaction/741599

Reaktionsgleichung

Beteiligte Stoffe

RolleNameHCIDEinwaage
Edukt5-(4-Chlorophenyl)-2-oxo-1,2-dihydropyridine-3-carbonitrileHCID 2763910—
LösungsmittelPhosphoric AcidHCID 1004—
Produkt5-(4-Chlorophenyl)-2-hydroxypyridineHCID 1026237275,6%

Reaktionsschritte

A mixture of 3-cyano-5-(4-chlorophenyl)-2-pyridinone (4.6 g) and 85% H3PO4 (60 ml) was heated at reflux for 16 hours. The resulting mixture was cooled to room temperature, poured into ice/water and filtered yielding 3.1 g of 5-(4-chlorophenyl)-2-pyridinone as a yellow solid.

Herkunft & Nachweise

DOI10.6084/m9.figshare.5104873.v1
PatentnummerUS05552409
Quelldatensatzuspto-grants-1996_09
ORD IDord-6db228fd149e45e99a81802ce5f7f075
Quellennotizuspto-grants-1996_09