Hydrochloric Acid → HCID 67498488, compound

Participants

Reaction Conditions

Reaction Steps

An eggplant flask was charged with 5-(benzothiazol-2-yl)-2-(N,N-dimethylaminomethyl)-1-(tetrahydropyran-4-yl)benzimidazole (see Working Example 9) (0.176 g, 0.448 mmol), anhydrous diethyl ether (1 mL), and anhydrous 1,4-dioxane (7 mL), and this was stirred at 0 to 5° C. To this was added slowly a solution of hydrogen chloride in diethyl ether (2.0 M, 2 mL), after which this was stirred under these conditions for 30 minutes. The generated crystals were filtered off, these were then washed with diethyl ether (approx. 2 mL, 3 times) and dried under reduced pressure to yield the title compound (0.186 g, 96.9% yield) as a pale yellow powder.

Provenance & Evidence