Methanol → HCID 19426801, compound

Participants

Reaction Steps

To a solution of the product of Step 2, above (11, 1.9 g, 5.8 mmol), in THF (10 ml) was added TMS-NCO (1.1 ml, 8.8 mmol), and the reaction mixture was stirred at room temperature for 2 hours. To the mixture was added methanol (5 ml) and the reaction mixture was stirred for 10 minutes and then solvent was removed by evaporation. The residue was chromatographed on silica gel (5% methanol/ethyl acetate) to give the crude title compound. Recrystallization from methanol/n-hexane/ethyl acetate afforded the title compound (12, 1.5 g, 67% yield) as colorless solids.

Provenance & Evidence