Trimethylsilyl triflate → HCID 131719535, compound

Participants

Reaction Steps

To a solution of the product of Step 4, above (16, 3.2 g, 6.2 mmol) in CH2Cl2 (30 ml) cooled to 0° C., was slowly added trimethylsilyl trifluoromethanesulfonate (2.5 ml, 13.4 mmol) under a nitrogen atmosphere. The reaction mixture was allowed to warm to room temperature and was stirred for 1.5 hours. The reaction mixture was poured carefully into ice cold water (30 ml), the organic layer was separated and the aqueous layer was extracted with CH2Cl2 (30 ml×3). The combined extracts were washed with aqueous NaHCO3 (50 ml) and brine (50 ml), then was dried (MgSO4) and solvent was removed under reduced pressure to afford the title compound (17, (1.8 g, 93% yield) as pale yellow solids.

Provenance & Evidence