Methanol → HCID 57215122, compound

Participants

Reaction Steps

Methyl (2S)-2-t-butoxycarbonylamino-4-[(1-methylimidazol-2-yl)carbamoyl]butyrate (341 mg) was dissolved in dichloromethane (5 ml), and trifluoroacetic acid (1 ml) was added. The mixture was stirred at room temperature for 2 hours. Methanol and toluene were added, and then the solvents were evaporated under reduced pressure. The resulting residue was dissolved in water (4 ml), and 1N sodium hydroxide (4 ml) was added. The mixture was stirred at room temperature for 3 hours and neutralized by adding 1N hydrochloric acid. The solvent was evaporated under reduced pressure to precipitate colorless needles. The needles were separated by filtration, washed successively with water, methanol and ether, and dried to give the title compound (72 mg).

Provenance & Evidence