Hydrochloride methanol → HCID 86749786, compound

HRID 741718Notes

Reaction equation

HRID 741718 reaction equation
C(OC([NH:8][C@H:9]([C:22](=[O:30])[NH:23][C:24]1[N:25]([CH3:29])[CH:26]=[CH:27][N:28]=1)[CH2:10][CH2:11][C:12]([O:14][CH2:15]C1C=CC=CC=1)=[O:13])=O)(C)(C)C.[ClH:31].CO>CO>[ClH:31].[ClH:31].[NH2:8][C@H:9]([C:22](=[O:30])[NH:23][C:24]1[N:25]([CH3:29])[CH:26]=[CH:27][N:28]=1)[CH2:10][CH2:11][C:12]([O:14][CH3:15])=[O:13]

Participants

4

Reactant 2

HCID 21893726Hydrochloride methanolHCID 57190203HCID 57190203, compound

Product 1

HCID 86749786HCID 86749786, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Benzyl (4S)-4-t-butoxycarbonylamino-4-[(1-methylimidazol-2-yl)carbamoyl]butyrate (113 mg) was dissolved in methanol (2.7 ml), and 20% hydrochloric acid-methanol (1.8 ml) was added. The mixture was stirred at room temperature for 2 hours. The solvent was evaporated under reduced pressure. The residue was triturated in ether, separated by filtration, washed with ether, and dried to give the title compound (83 mg).

Workup

  1. customThe solvent was evaporated under reduced pressure
  2. customThe residue was triturated in ether
  3. customseparated by filtration
  4. washwashed with ether
  5. customdried

Sources & evidence

ORD record
ord-a57e8a36eb734fcb9e3c440aa586d8c7
Source dataset
uspto-grants-1996_09
Patent number
US05552427

Reaction notes

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