Morpholine → HCID 15388686, compound

HRID 741736Notes

Reaction equation

HRID 741736 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH2:7]([N:14]1[C:18]2[CH:19]=[C:20]([O:23][CH2:24][CH2:25][CH2:26]Cl)[CH:21]=[CH:22][C:17]=2[N:16]=[C:15]1[C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([CH3:34])[CH:29]=1)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.C(C1C=CC=CC=1N(C(C)C)CC)(C)C>C(#N)C>[CH2:7]([N:14]1[C:18]2[CH:19]=[C:20]([O:23][CH2:24][CH2:25][CH2:26][N:1]3[CH2:6][CH2:5][O:4][CH2:3][CH2:2]3)[CH:21]=[CH:22][C:17]=2[N:16]=[C:15]1[C:28]1[CH:33]=[CH:32][CH:31]=[C:30]([CH3:34])[CH:29]=1)[C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1

Participants

5

Reactant 3

HCID 8083MorpholineHCID 19353966HCID 19353966, compoundHCID 50937077HCID 50937077, compound

Product 1

HCID 15388686HCID 15388686, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

The title compound was prepared by first adding morpholine (1.02 g, 11.77 mmol) and the compound of Example 97, supra, (0.39 g, 1.00 mmol) to 125 ml of acetonitrile while stirring under nitrogen purge. To this mixture is then added diisopropylethyl aniline (1.51 ml, 8.67 mmol) dropwise. This reaction mixture is then allowed to stir overnight.

Workup

  1. custompurge

Sources & evidence

ORD record
ord-a0e0d64858a44dd682470009c011f9e3
Source dataset
uspto-grants-1996_09
Patent number
US05552426

Reaction notes

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