反应详情

To a suspension of CrO3 (1.1 g, 11 mmol) in CH2Cl2 at r.t. was added pyridine (1.8 mL, 22 mmol) and the resulting mixture was stirred for 20 min.. The alcohol from Step 1 in CH2Cl2 was added and the resulting mixture was stirred for 16 h. Then ET2O was added and the resulting mixture was filtered through silica gel and washed with Et2O. After evaporation the residue was chromatographed on silica gel eluting with 7:3 mixture of hexane:EtOAc to give 1.66 g (90%) of the title compound.

1. stirringthe resulting mixture was stirred for 16 h
2. additionThen ET2O was added
3. filtrationthe resulting mixture was filtered through silica gel
4. washwashed with Et2O
5. customAfter evaporation the residue
6. customwas chromatographed on silica gel eluting with 7:3 mixture of hexane