5-Fluoro-3-(hexafluoro-2-hydroxyprop-2-yl)-1-(2-trimethylsilylethylthio)benzene → 5-Fluoro-3-[3-hydroxy-3-(thiazol-2-yl)propen-3-yl]thiophenol

HRID 741808Notes

Reaction equation

HRID 741808 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([C:8]([OH:16])([C:11]2[S:12][CH:13]=[CH:14][N:15]=2)[CH:9]=[CH2:10])[CH:5]=[C:4](F)[CH:3]=1.FC1C=C(C(O)(C(F)(F)F)C(F)(F)F)C=C([S:25]CC[Si](C)(C)C)C=1>>[F:1][C:2]1[CH:7]=[C:6]([C:8]([OH:16])([C:11]2[S:12][CH:13]=[CH:14][N:15]=2)[CH:9]=[CH2:10])[CH:5]=[C:4]([SH:25])[CH:3]=1

Participants

3

Reactant 2

HCID 194269565-Fluoro-3-(hexafluoro-2-hydroxyprop-2-yl)-1-(2-trimethylsilylethylthio)benzeneHCID 194269861,3-Difluoro-5-[3-hydroxy-3-(thiazol-2-yl)propen-3-yl]benzene

Product 1

HCID 194269925-Fluoro-3-[3-hydroxy-3-(thiazol-2-yl)propen-3-yl]thiophenol

Procedure

Following the procedure described for Thiophenol 1, Step 3, but substituting the 5-fluoro-3-[3-hydroxy-3-(thiazol-2-yl)propen-3-yl]-1-(2-trimethylsilylethylthio)benzene from Step 4 for 5-fluoro-3-(hexafluoro-2-hydroxyprop-2-yl)-1-(2-trimethylsilylethylthio)benzene as starting material, the title compound was obtained.

Sources & evidence

ORD record
ord-e7565a2d55834bfd939d527081378c2c
Source dataset
uspto-grants-1996_09
Patent number
US05552437

Reaction notes

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