HuagongsheHuagongshe Chemistry Print Report · For research reference only
Thiophenol → 5-Fluoro-3-[1-hydroxy-1-(thiazol-2-yl)propyl]thiophenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Thiophenol | HCID 7969 | — |
| Reactant | (3,5-Difluorophenyl)(thiazol-2-yl)methanone | HCID 19426944 | — |
| Reactant | HCID 178418443 | HCID 178418443 | — |
| Reactant | HCID 178418507 | HCID 178418507 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 5-Fluoro-3-[1-hydroxy-1-(thiazol-2-yl)propyl]thiophenol | HCID 19426959 | — |
Reaction Steps
Following the procedure described for Thiophenol 2, Step 3 and thiophenol 5, Steps 2 and 3 but substituting the ketone from Thiophenol 5, Step 1 for (3,5-difluorophenyl)(thiazol-2-yl)methanone and ethylmagnesium bromide in THF (Aldrich) for vinylmagnesium bromide as starting material the title compound was obtained. Mass spec. 270 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05552437 |
| Source dataset | uspto-grants-1996_09 |
| ORD ID | ord-11bc7ba530e647759b60974d31650ec3 |
| Source note | uspto-grants-1996_09 |