Methyl iodide → HCID 19426980, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of alcohol from Step 1 (740 mg, 2.03 mmol) in 20 mL THF at 0° C. was added KH (466 mg, 4.06 mmol, 35% in oil). After 10 min. MeI (1.44 g, 10.1 mmol) was added dropwise. The solution was stirred for 30 min. at 0° C., then poured into an aqueous saturated NH4C1. The aqueous layer was extracted with EtOAc (3×25 mL) and the combined organic layers were washed with brine and dried over anhydrous MgSO4. Evaporation of the solvent and flash chromatography on silica gel (hexane:EtOAc=9:1) gave the title compound (1.2 g) which was used directly in the next step.

Provenance & Evidence