HuagongsheHuagongshe Chemistry Print Report · For research reference only
Tetrabutylammonium Fluoride → 2-Cyano-4-(3-furyl)-7-mercaptonaphthalene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Tetrabutylammonium Fluoride | HCID 2724141 | — |
| Reactant | 3-Cyano-1-(furan-3-yl)-6-[2-trimethylsilylethylthio]naphthalene | HCID 19426971 | — |
| Solvent | Hydrochloric Acid | HCID 313 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 2-Cyano-4-(3-furyl)-7-mercaptonaphthalene | HCID 23370231 | 82.4% |
Reaction Steps
The product from Step 1 (1.8 g) was dissolved in DMF (40 mL) and there was added n-Bu4NF (1M) in THF (15 mL). The resulting mixture was stirred at r.t. for 1.5 h, diluted with 1N aqueous HCl (40 mL) then H2O (300 mL) and filtered to afford the title thiol (1.06 g) as a light orange solid m.p.: 144°-146° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05552437 |
| Source dataset | uspto-grants-1996_09 |
| ORD ID | ord-a737a7ab637e4d72a3fcf62e015646b0 |
| Source note | uspto-grants-1996_09 |