Methyl chloroformate → HCID 22865250, compound

Participants

Reaction Steps

314 mg (1 mmol) of 3-(5-(S)-(3-aminopropyl)-2,4-dioxoimidazolidin-3-yl)-benzoic acid hydrochloride are dissolved in 5 ml of methanol and 5 ml of water. After addition of 130 mg (1.38 mmol) of methyl chloroformate, the mixture is adjusted to pH 7 at 10° C. with 0.1 N sodium hydroxide solution. The mixture is allowed to warm to room temperature, and is stirred for 4 h, acidified to pH 3 with potassium hydrogen sulphate solution and concentrated. The residue is stirred with water, filtered off with suction and dried.

Provenance & Evidence