HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-(3-Chloro-2-methylphenyl)-1-methyl-2-thioxo-imidazolidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 1-Chloro-3-isothiocyanato-2-methylbenzene | HCID 140504 | — |
| Reactant | Ethyl N-methylaminoacetate hydrochloride | HCID 171173 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 3-(3-Chloro-2-methylphenyl)-1-methyl-2-thioxo-imidazolidin-4-one | HCID 18968212 | 83.3% |
Reaction Steps
The title compound was prepared by the procedure described in Example 1 using 13.2 g of 3-chloro-2-methylphenyl-isothiocyanate, 11.0 g of sarcosine ethyl ester hydrochloride, 25 g of triethyl amine, and 300 mL of chloroform. Crystallization from diethyl ether afforded the title compound (15.2 g) as a tan solid, m.p. 122°-124° C. Anal. Calcd. for C11H11Cl N2O S: C, 51.87; H, 4.35; N,11.00. Found: C, 51.96; H, 4.21; N, 11.05. Mass spectrum (EI, M.+) m/z 254/256.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05554607 |
| Source dataset | uspto-grants-1996_09 |
| ORD ID | ord-e1176e7dc4fa4fa3bf374c0dee41fffa |
| Source note | uspto-grants-1996_09 |