HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 3-(2,6-Diisopropylphenyl)-1-methyl-2-thioxo-imidazolidin-4-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Isothiocyanato-1,3-bis(propan-2-yl)benzene | HCID 141194 | — |
| Reactant | Ethyl N-methylaminoacetate hydrochloride | HCID 171173 | — |
| Solvent | Chloroform | HCID 6212 | — |
| Product | 3-(2,6-Diisopropylphenyl)-1-methyl-2-thioxo-imidazolidin-4-one | HCID 85701468 | 60.2% |
Reaction Steps
The title compound was prepared by the procedure described in Example 1 using 8.3 g of 2,6-diisopropylphenyl-isothiocyanate, 5.8 g of sarcosine ethyl ester hydrochloride, 14.5 g of triethyl amine, and 200 mL of chloroform. Crystallization from diethyl ether/hexane mixture afforded the title compound (6.6 g) as a tan solid, m.p. 174°-176° C. Anal. Calcd. for C16H22N2O S: C, 66.17; H, 7.63; N, 9.64. Found: C, 66.39; H, 7.63; N, 9.59. Mass spectrum (+FAB, [M+H]+) m/z 269/271.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05554607 |
| Source dataset | uspto-grants-1996_09 |
| ORD ID | ord-362b1f6739e240bb88908bd4ef3d3d4a |
| Source note | uspto-grants-1996_09 |